MolNFT v1 · #113684 · protein + RNA
Structure of the la crosse bunyavirus polymerase in complex with the 3' and 5' viral RNA
5AMQ · RNA polymerase L: “Structure of the la crosse bunyavirus polymerase in complex with the 3' and 5' viral RNA”. X-ray diffraction, 20 pockets (best druggability 0.78). MolNFT v1 #113684 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5AMQ
- Type
- protein + RNA
- Length
- 1,700 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase L; RNA
- UniProt
- A5HC98
- Pockets
- 20 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 52% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase L | protein | 1666 | 52% helix, 11% strand | A5HC98 |
| B | RNA | rna | 16 | — | — |
| C | RNA | rna | 10 | — | — |
| c | RNA | rna | 8 | — | — |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 354 | 0.78 | 0.88 | 32 | empty |
| 2 | 1164 | 0.76 | 0.79 | 73 | empty |
| 3 | 644 | 0.75 | 0.81 | 73 | empty |
| 4 | 470 | 0.75 | 0.83 | 41 | empty |
| 5 | 349 | 0.67 | 0.81 | 39 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1738 Ų buried · 37 hydrogen bonds · protein-nucleic
- A–C · 1450 Ų buried · 47 hydrogen bonds · protein-nucleic
- B–c · 375 Ų buried · 30 hydrogen bonds · nucleic-nucleic
- A–c · 254 Ų buried · 5 hydrogen bonds · protein-nucleic
Compared structures
- 5AMQ · Structure of the La Crosse Bunyavirus polymerase in complex with the 3' and 5' viral RNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A5HC98
- Elsewhere: RCSB PDB 5AMQ · PDBe 5AMQ · UniProt A5HC98
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