MolNFT v1 · #11363 · protein
Structural basis for the recognition of a nucleoporin fg- repeat by the NTF2-like domain of tap-P15 mRNA nuclear export factor
1JKG: “Structural basis for the recognition of a nucleoporin fg- repeat by the NTF2-like domain of tap-P15 mRNA…”. X-ray diffraction, 6 pockets (best druggability 0.58). MolNFT v1 #11363 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1JKG
- Type
- protein
- Length
- 319 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- P15; Tap
- UniProt
- Q9UKK6, Q9UBU9
- Pockets
- 6 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | P15 | protein | 139 | 30% helix, 43% strand | Q9UKK6 |
| B | Tap | protein | 180 | 30% helix, 33% strand | Q9UBU9 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.58 | 0.83 | 29 | empty |
| 2 | 85 | 0.43 | 0.79 | 22 | empty |
| 3 | 124 | 0.42 | 0.76 | 27 | empty |
| 4 | 64 | 0.33 | 0.76 | 15 | empty |
| 5 | 53 | 0.29 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2069 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 1JKG · Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UKK6 · AlphaFold monomer V2.0 prediction for NTF2-related export protein 1 (Q9UKK6) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9UBU9 · AlphaFold monomer V2.0 prediction for nuclear RNA export factor 1 (Q9UBU9) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UKK6
- Every structure of UniProt Q9UBU9
- Elsewhere: RCSB PDB 1JKG · PDBe 1JKG · UniProt Q9UKK6 · UniProt Q9UBU9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.