Crystal structure of salmonalla enterica hisa mutant D7N with profar

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 25% strand (DSSP).

Ligands and binding sites

• GUO · [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S, 5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate · ligand · chains A
• PO4 · Phosphate ion · ion · chains A
• CL · Chloride ion · ion · chains A
• GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 5AHI · Crystal structure of salmonalla enterica HisA mutant D7N with ProFAR · the same entry in another collection · chain A against A, TM-score 1.00
• P10372 · AlphaFold monomer V2.0 prediction for 1-(5-phosphoribosyl)-5-[(5-PHOSPHORIBOSYLAMINO)METHY… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P10372
• Elsewhere: RCSB PDB 5AHI · PDBe 5AHI · UniProt P10372