MolNFT v1 · #113416 · protein
Neuronal calcium sensor (ncs-1)FROM rattus norvegicus
5AEQ · Neuronal calcium sensor 1: “Neuronal calcium sensor (ncs-1)FROM rattus norvegicus”. X-ray diffraction, 2 ligands (CA, NA), 5 pockets (best druggability 0.73). MolNFT v1 #113416 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5AEQ
- Type
- protein
- Length
- 343 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neuronal calcium sensor 1
- UniProt
- P62168
- Ligands
- CA, NA
- Pockets
- 5 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neuronal calcium sensor 1 | protein | 172 | 63% helix, 6% strand | P62168 |
| B | Neuronal calcium sensor 1 | protein | 171 | 68% helix, 4% strand | P62168 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 883 | 0.73 | 0.77 | 53 | empty |
| 2 | 463 | 0.62 | 0.75 | 35 | empty |
| 3 | 256 | 0.56 | 0.77 | 32 | empty |
| 4 | 54 | 0.29 | 0.75 | 13 | empty |
| 5 | 53 | 0.24 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 359 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62168
- Elsewhere: RCSB PDB 5AEQ · PDBe 5AEQ · UniProt P62168
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.