MolNFT v1 · #113319 · protein
Complex of C. elegans EIF4E-3 with the 4E-binding protein mextli and cap analog
5ABX · Eukaryotic translation initiation factor 4E-3: “Complex of C. elegans EIF4E-3 with the 4E-binding protein mextli and cap analog”. X-ray diffraction, 3 ligands (MGP, ZN, CL), 1 pocket (best druggability 0.38). MolNFT v1 #113319 on…
- PDB
- 5ABX
- Type
- protein
- Length
- 211 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E-3; 4E-binding protein mextli
- UniProt
- O61955, Q9XW13
- Ligands
- MGP, ZN, CL
- Pockets
- 1 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E-3 | protein | 173 | 33% helix, 31% strand | O61955 |
| B | 4E-binding protein mextli | protein | 38 | 53% helix, 3% strand | Q9XW13 |
Ligands and binding sites
- MGP · 7-methyl-guanosine-5'-triphosphate · ligand · chains A
- ZN · Zinc ion · metal · 4 copies · chains A, B
- CL · Chloride ion · ion · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.38 | 0.77 | 15 | MGP |
Interfaces
1 interface between chains.
- A–B · 1336 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 5ABX · Complex of C. elegans eIF4E-3 with the 4E-binding protein Mextli and cap analog · the same entry in another collection · chain A against A, TM-score 1.00
- O61955 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-3… · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9XW13 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-binding… · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O61955
- Every structure of UniProt Q9XW13
- Elsewhere: RCSB PDB 5ABX · PDBe 5ABX · UniProt O61955 · UniProt Q9XW13
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