MolNFT v1 · #113315 · protein

S.ENTERICA hisa mutant D7N, G102A, V106M, D176A

5ABT · 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylidene…: “S.ENTERICA hisa mutant D7N, G102A, V106M, D176A”. X-ray diffraction, 1 ligand (GUO), 1 pocket (best druggability 0.86). MolNFT v1 #113315 on GenesisL1: 3D structure…

PDB: 5ABT
Type: protein
Length: 246 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylidene amino]…
EC: 5.3.1.16
UniProt: V7IJE3
Ligands: GUO
Pockets: 1 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylidene amino] imidazole-4-carboxamide isomerase (EC 5.3.1.16)	protein	246	40% helix, 25% strand	V7IJE3

Ligands and binding sites

GUO · [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S, 5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	287	0.86	0.96	46	GUO

Compared structures

5ABT · S.enterica HisA mutant D7N, G102A, V106M, D176A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt V7IJE3
Elsewhere: RCSB PDB 5ABT · PDBe 5ABT · UniProt V7IJE3

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