MolNFT v1 · #113119 · protein
Structure of mammalian EIF3 in the context of the 43S preinitiation complex
5A5T · Eukaryotic translation initiation factor 3 subunit a: “Structure of mammalian EIF3 in the context of the 43S preinitiation complex”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #113119 on GenesisL1: 3D…
- PDB
- 5A5T
- Type
- protein
- Length
- 3,123 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit a; Eukaryotic translation initiation…
- EC
- 3.4.19.12
- UniProt
- G1SMZ5, G1U971, G1SUC8, U3KNL5, G1ST95, G1T3L2, G1SED9, G1SLW8
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 8 distinct chains · 64% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 3 subunit a | protein | 599 | 74% helix, 1% strand | G1SMZ5 |
| C | Eukaryotic translation initiation factor 3 subunit C | protein | 557 | 68% helix, 2% strand | G1U971 |
| E | Eukaryotic translation initiation factor 3 subunit E | protein | 419 | 63% helix, 2% strand | G1SUC8 |
| F | Eukaryotic translation initiation factor 3 subunit F (EC 3.4.19.12) | protein | 272 | 47% helix, 21% strand | U3KNL5 |
| H | Eukaryotic translation initiation factor 3 subunit H | protein | 324 | 49% helix, 13% strand | G1ST95 |
| K | Eukaryotic translation initiation factor 3 subunit K | protein | 215 | 62% helix, 3% strand | G1T3L2 |
| L | Uncharacterized protein | protein | 372 | 63% helix, 3% strand | G1SED9 |
| M | Eukaryotic translation initiation factor 3 subunit M | protein | 365 | 65% helix, 0% strand | G1SLW8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1082 | 0.87 | 0.87 | 115 | empty |
| 2 | 409 | 0.83 | 0.91 | 43 | empty |
| 3 | 1147 | 0.82 | 0.83 | 108 | empty |
| 4 | 434 | 0.81 | 0.89 | 48 | empty |
| 5 | 163 | 0.81 | 0.96 | 33 | empty |
Interfaces
18 interfaces between chains.
- F–H · 3743 Ų buried · 36 hydrogen bonds · protein-protein
- A–C · 2789 Ų buried · 38 hydrogen bonds · protein-protein
- F–M · 2406 Ų buried · 39 hydrogen bonds · protein-protein
- K–L · 2388 Ų buried · 40 hydrogen bonds · protein-protein
- C–E · 1994 Ų buried · 40 hydrogen bonds · protein-protein
Compared structures
- 5A5T · Structure of mammalian eIF3 in the context of the 43S preinitiation complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G1SMZ5
- Every structure of UniProt G1U971
- Every structure of UniProt G1SUC8
- Every structure of UniProt U3KNL5
- Every structure of UniProt G1ST95
- Every structure of UniProt G1T3L2
- Every structure of UniProt G1SED9
- Every structure of UniProt G1SLW8
- Elsewhere: RCSB PDB 5A5T · PDBe 5A5T · UniProt G1SMZ5 · UniProt G1U971 · UniProt G1SUC8 · UniProt U3KNL5 · UniProt G1ST95 · UniProt G1T3L2 · UniProt G1SED9 · UniProt G1SLW8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.