Research workbench
Structure of mammalian EIF3 in the context of the 43S preinitiation complex
Analyse Structure of mammalian EIF3 in the context of the 43S preinitiation complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5A5T
- Type
- protein
- Length
- 3,123 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit a; Eukaryotic translation initiation…
- EC
- 3.4.19.12
- UniProt
- G1SMZ5, G1U971, G1SUC8, U3KNL5, G1ST95, G1T3L2, G1SED9, G1SLW8
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 8 distinct chains · 64% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 3 subunit a | protein | 599 | 74% helix, 1% strand | G1SMZ5 |
| C | Eukaryotic translation initiation factor 3 subunit C | protein | 557 | 68% helix, 2% strand | G1U971 |
| E | Eukaryotic translation initiation factor 3 subunit E | protein | 419 | 63% helix, 2% strand | G1SUC8 |
| F | Eukaryotic translation initiation factor 3 subunit F (EC 3.4.19.12) | protein | 272 | 47% helix, 21% strand | U3KNL5 |
| H | Eukaryotic translation initiation factor 3 subunit H | protein | 324 | 49% helix, 13% strand | G1ST95 |
| K | Eukaryotic translation initiation factor 3 subunit K | protein | 215 | 62% helix, 3% strand | G1T3L2 |
| L | Uncharacterized protein | protein | 372 | 63% helix, 3% strand | G1SED9 |
| M | Eukaryotic translation initiation factor 3 subunit M | protein | 365 | 65% helix, 0% strand | G1SLW8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1082 | 0.87 | 0.87 | 115 | empty |
| 2 | 409 | 0.83 | 0.91 | 43 | empty |
| 3 | 1147 | 0.82 | 0.83 | 108 | empty |
| 4 | 434 | 0.81 | 0.89 | 48 | empty |
| 5 | 163 | 0.81 | 0.96 | 33 | empty |
Interfaces
18 interfaces between chains.
- F–H · 3743 Ų buried · 36 hydrogen bonds · protein-protein
- A–C · 2789 Ų buried · 38 hydrogen bonds · protein-protein
- F–M · 2406 Ų buried · 39 hydrogen bonds · protein-protein
- K–L · 2388 Ų buried · 40 hydrogen bonds · protein-protein
- C–E · 1994 Ų buried · 40 hydrogen bonds · protein-protein
Compared structures
- 5A5T · Structure of mammalian eIF3 in the context of the 43S preinitiation complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G1SMZ5
- Every structure of UniProt G1U971
- Every structure of UniProt G1SUC8
- Every structure of UniProt U3KNL5
- Every structure of UniProt G1ST95
- Every structure of UniProt G1T3L2
- Every structure of UniProt G1SED9
- Every structure of UniProt G1SLW8
- Elsewhere: RCSB PDB 5A5T · PDBe 5A5T · UniProt G1SMZ5 · UniProt G1U971 · UniProt G1SUC8 · UniProt U3KNL5 · UniProt G1ST95 · UniProt G1T3L2 · UniProt G1SED9 · UniProt G1SLW8
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