MolNFT v1 · #11297 · protein

Crystal structure of bleomycin-binding protein from bleomycin-producing streptomyces verticillus complexed with COPPER(II)-bleomycin

1JIF: “Crystal structure of bleomycin-binding protein from bleomycin-producing streptomyces verticillus complexed…”. X-ray diffraction, 3 ligands (BLM, CU, CL), 1 pocket (best druggability 0.31). MolNFT v1 #11297 on GenesisL1: 3D…

PDB: 1JIF
Type: protein
Length: 244 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bleomycin-binding protein
UniProt: Q53793
Ligands: BLM, CU, CL
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 1 distinct chain · 20% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Bleomycin-binding protein	protein	122	20% helix, 43% strand	Q53793

Ligands and binding sites

BLM · Bleomycin A2 · ligand · 2 copies · chains A, B
CU · Copper (II) ion · metal · 2 copies
CL · Chloride ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.31	0.75	17	empty

Interfaces

1 interface between chains.

A–B · 1604 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1JIF · Crystal structure of bleomycin-binding protein from bleomycin-producing Streptomyces… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q53793
Elsewhere: RCSB PDB 1JIF · PDBe 1JIF · UniProt Q53793

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