MolNFT v1 · #112801 · protein
Crystal structure of maltose-bound human GLUT3 in the outward-occluded conformation at 2.4 ångström
4ZWB · Solute carrier family 2, facilitated glucose transporter…: “Crystal structure of maltose-bound human GLUT3 in the outward-occluded conformation at 2.4 ångström”. X-ray diffraction, 1 ligand (GLC), 5 pockets (best druggability 0.79).…
- PDB
- 4ZWB
- Type
- protein
- Length
- 468 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Solute carrier family 2, facilitated glucose transporter member 3
- UniProt
- P11169
- Ligands
- GLC
- Pockets
- 5 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Solute carrier family 2, facilitated glucose transporter member 3 | protein | 468 | 79% helix, 0% strand | P11169 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 633 | 0.79 | 0.84 | 60 | GLC |
| 2 | 56 | 0.63 | 0.93 | 20 | empty |
| 3 | 84 | 0.35 | 0.76 | 19 | empty |
| 4 | 58 | 0.35 | 0.77 | 11 | empty |
| 5 | 74 | 0.32 | 0.74 | 13 | empty |
Compared structures
- 4ZWB · Crystal structure of maltose-bound human GLUT3 in the outward-occluded conformation at… · the same entry in another collection · chain A against A, TM-score 1.00
- P11169 · AlphaFold monomer V2.0 prediction for solute carrier family 2, facilitated glucose… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11169
- Elsewhere: RCSB PDB 4ZWB · PDBe 4ZWB · UniProt P11169
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