MolNFT v1 · #112727 · protein
Crystal structure of O-acetylserine sulfhydrylase from haemophilus influenzae in complex with O-acetyl serine and peptide inhibitor
4ZU1 · Cysteine synthase: “Crystal structure of O-acetylserine sulfhydrylase from haemophilus influenzae in complex with O-acetyl serine…”. X-ray diffraction, 1 ligand (OAS), 1 pocket (best druggability 0.42). MolNFT v1 #112727 on…
- PDB
- 4ZU1
- Type
- protein
- Length
- 318 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine synthase; C-terminal peptide from serine acetyltransferase
- EC
- 2.5.1.47
- UniProt
- P45040, P29847
- Ligands
- OAS
- Pockets
- 1 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | Cysteine synthase (EC 2.5.1.47) | protein | 310 | 41% helix, 17% strand | P45040 |
| A | C-terminal peptide from serine acetyltransferase | protein | 8 | 0% helix, 13% strand | P29847 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.42 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- X–A · 685 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (cofactor).
Compared structures
- 4ZU1 · Crystal Structure of O-Acetylserine Sulfhydrylase from Haemophilus influenzae in complex… · the same entry in another collection · chain X against X, TM-score 1.00
- P45040 · AlphaFold monomer V2.0 prediction for cysteine synthase (P45040) · a predicted model of the same protein · chain X against A, TM-score 0.99
- P29847 · AlphaFold monomer V2.0 prediction for serine acetyltransferase (P29847) · a predicted model of the same protein · chain A against A, TM-score 0.28
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P45040
- Every structure of UniProt P29847
- Elsewhere: RCSB PDB 4ZU1 · PDBe 4ZU1 · UniProt P45040 · UniProt P29847
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.