MolNFT v1 · #11269 · protein

Crystal structure of the lumenal domain of calnexin

1JHN: “Crystal structure of the lumenal domain of calnexin”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.56). MolNFT v1 #11269 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1JHN
Type: protein
Length: 380 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calnexin
UniProt: P24643
Ligands: CA
Pockets: 3 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calnexin	protein	380	5% helix, 29% strand	P24643

Ligands and binding sites

CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	158	0.56	0.81	25	empty
2	65	0.41	0.81	15	empty
3	61	0.33	0.77	20	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1JHN · Crystal Structure of the Lumenal Domain of Calnexin · the same entry in another collection · chain A against A, TM-score 1.00
P24643 · AlphaFold monomer V2.0 prediction for calnexin (P24643) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P24643
Elsewhere: RCSB PDB 1JHN · PDBe 1JHN · UniProt P24643

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