MolNFT v1 · #11261 · protein
Lexa G85D mutant
1JHF · Lexa repressor: “Lexa G85D mutant”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.51). MolNFT v1 #11261 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1JHF
- Type
- protein
- Length
- 308 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lexa repressor
- EC
- 3.4.21.88
- UniProt
- P0A7C2
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lexa repressor (EC 3.4.21.88) | protein | 197 | 23% helix, 32% strand | P0A7C2 |
| B | Lexa repressor (EC 3.4.21.88) | protein | 111 | 5% helix, 48% strand | P0A7C2 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 244 | 0.51 | 0.75 | 23 | empty |
| 2 | 97 | 0.44 | 0.79 | 19 | empty |
| 3 | 93 | 0.35 | 0.74 | 14 | empty |
| 4 | 75 | 0.34 | 0.75 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 698 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A7C2
- Elsewhere: RCSB PDB 1JHF · PDBe 1JHF · UniProt P0A7C2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.