MolNFT v1 · #112508 · protein
IGG1 Fc-fcgammari ecd complex
4ZNE · High affinity immunoglobulin gamma Fc receptor I: “IGG1 Fc-fcgammari ecd complex”. X-ray diffraction, 4 ligands (NAG, MAN, FUL), 3 pockets (best druggability 0.39). MolNFT v1 #112508 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4ZNE
- Type
- protein
- Length
- 666 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- High affinity immunoglobulin gamma Fc receptor I; Ig gamma-1 chain C region
- UniProt
- P12314, P01857
- Ligands
- NAG, MAN, FUL, ZN
- Pockets
- 3 · best druggability 0.39
Structure
x-ray diffraction · 3 distinct chains · 9% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | High affinity immunoglobulin gamma Fc receptor I | protein | 242 | 5% helix, 54% strand | P12314 |
| E | Ig gamma-1 chain C region | protein | 215 | 11% helix, 47% strand | P01857 |
| J | Ig gamma-1 chain C region | protein | 209 | 11% helix, 47% strand | P01857 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 15 copies · chains A, E, J
- MAN · alpha-D-mannopyranose · sugar · 8 copies · chains E, J
- FUL · beta-L-fucopyranose · sugar · 2 copies · chains E
- ZN · Zinc ion · metal · 3 copies · chains A, E, J
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.39 | 0.78 | 20 | empty |
| 2 | 74 | 0.31 | 0.74 | 19 | empty |
| 3 | 56 | 0.30 | 0.76 | 17 | empty |
Interfaces
3 interfaces between chains.
- E–J · 1149 Ų buried · 5 hydrogen bonds · protein-protein
- A–E · 663 Ų buried · 4 hydrogen bonds · protein-protein
- A–J · 467 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide, 7 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12314
- Every structure of UniProt P01857
- Elsewhere: RCSB PDB 4ZNE · PDBe 4ZNE · UniProt P12314 · UniProt P01857
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