MolNFT v1 · #112269 · protein

Structure of untreated lipase from thermomyces lanuginosa at 2.3 a resolution

4ZGB: “Structure of untreated lipase from thermomyces lanuginosa at 2.3 a resolution”. X-ray diffraction, 4 pockets (best druggability 0.59). MolNFT v1 #112269 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4ZGB
Type: protein
Length: 538 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipase
EC: 3.1.1.3
UniProt: O59952
Pockets: 4 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Lipase (EC 3.1.1.3)	protein	269	30% helix, 24% strand	O59952

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	234	0.59	0.80	40	empty
2	90	0.39	0.77	22	empty
3	88	0.33	0.74	18	empty
4	53	0.28	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 579 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

4ZGB · Structure of untreated lipase from Thermomyces lanuginosa at 2.3 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
O59952 · AlphaFold monomer V2.0 prediction for lipase (O59952) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O59952
Elsewhere: RCSB PDB 4ZGB · PDBe 4ZGB · UniProt O59952

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