MolNFT v1 · #112262 · protein
Myosin vc pre-powerstroke
4ZG4 · Myosin-vc: “Myosin vc pre-powerstroke”. X-ray diffraction, 3 ligands (ADP, MG, VO4), 20 pockets (best druggability 0.68). MolNFT v1 #112262 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4ZG4
- Type
- protein
- Length
- 1,416 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-vc
- UniProt
- Q9NQX4
- Ligands
- ADP, MG, VO4
- Pockets
- 20 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Myosin-vc | protein | 705 | 45% helix, 16% strand | Q9NQX4 |
| E | Myosin-vc | protein | 711 | 44% helix, 16% strand | Q9NQX4 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains B, E
- MG · Magnesium ion · metal · 2 copies · chains B, E
- VO4 · Vanadate ion · ion · 2 copies · chains B, E
- EDO · 1,2-ethanediol · additive · chains B, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 452 | 0.68 | 0.80 | 51 | MG, VO4, ADP |
| 2 | 498 | 0.67 | 0.78 | 58 | MG, VO4, ADP |
| 3 | 670 | 0.65 | 0.75 | 86 | EDO |
| 4 | 78 | 0.62 | 0.90 | 27 | empty |
| 5 | 330 | 0.62 | 0.79 | 47 | empty |
Interfaces
1 interface between chains.
- B–E · 726 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- Q9NQX4 · AlphaFold monomer V2.0 prediction for unconventional myosin-vc (Q9NQX4) · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NQX4
- Elsewhere: RCSB PDB 4ZG4 · PDBe 4ZG4 · UniProt Q9NQX4
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