MolNFT v1 · #112192 · protein
Crystal structure of importin-alpha bound to a non-classical nuclear localization signal of the influenza a virus nucleoprotein
4ZDU · Importin subunit alpha-1: “Crystal structure of importin-alpha bound to a non-classical nuclear localization signal of the influenza a…”. X-ray diffraction, 1 pocket (best druggability 0.45). MolNFT v1 #112192 on GenesisL1: 3D…
- PDB
- 4ZDU
- Type
- protein
- Length
- 428 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Peptide from nucleoprotein
- UniProt
- P52293, P03466
- Pockets
- 1 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-1 | protein | 416 | 76% helix, 0% strand | P52293 |
| B | Peptide from nucleoprotein | protein | 12 | 33% helix, 0% strand | P03466 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.45 | 0.82 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 725 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 4ZDU · Crystal structure of importin-alpha bound to a non-classical nuclear localization signal… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt P03466
- Elsewhere: RCSB PDB 4ZDU · PDBe 4ZDU · UniProt P52293 · UniProt P03466
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