MolNFT v1 · #112045 · protein
Crystal structure of DNMT1 in complex with USP7
4Z96 · Ubiquitin carboxyl-terminal hydrolase 7: “Crystal structure of DNMT1 in complex with USP7”. X-ray diffraction, 4 pockets (best druggability 0.61). MolNFT v1 #112045 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4Z96
- Type
- protein
- Length
- 531 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin carboxyl-terminal hydrolase 7; DNA (cytosine-5)-methyltransferase 1
- EC
- 3.4.19.12, 2.1.1.37
- UniProt
- Q93009, P26358
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) | protein | 523 | 22% helix, 32% strand | Q93009 |
| C | DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) | protein | 8 | 0% helix, 0% strand | P26358 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 172 | 0.61 | 0.83 | 30 | empty |
| 2 | 152 | 0.55 | 0.81 | 24 | empty |
| 3 | 162 | 0.44 | 0.74 | 35 | empty |
| 4 | 75 | 0.29 | 0.72 | 14 | empty |
Interfaces
1 interface between chains.
- A–C · 702 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q93009
- Every structure of UniProt P26358
- Elsewhere: RCSB PDB 4Z96 · PDBe 4Z96 · UniProt Q93009 · UniProt P26358
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.