MolNFT v1 · #112021 · protein

Tead dbd mutant -DELTAL1

4Z8E · Transcriptional enhancer factor tef-1: “Tead dbd mutant -DELTAL1”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #112021 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4Z8E
Type: protein
Length: 172 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional enhancer factor tef-1
UniProt: P28347
Pockets: 1 · best druggability 0.33

Structure

x-ray diffraction · 3 distinct chains · 66% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional enhancer factor tef-1	protein	59	64% helix, 0% strand	P28347
B	Transcriptional enhancer factor tef-1	protein	58	66% helix, 0% strand	P28347
C	Transcriptional enhancer factor tef-1	protein	55	69% helix, 0% strand	P28347

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	98	0.33	0.72	13	empty

Interfaces

2 interfaces between chains.

A–C · 691 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 119 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

4Z8E · TEAD DBD mutant -deltaL1 · the same entry in another collection · chain A against A, TM-score 1.00
P28347 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-1 (P28347) · a predicted model of the same protein · chain C against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28347
Elsewhere: RCSB PDB 4Z8E · PDBe 4Z8E · UniProt P28347

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.