MolNFT v1 · #111853 · protein

Crystal structure of the roq domain of human roquin-2

4Z30: “Crystal structure of the roq domain of human roquin-2”. X-ray diffraction, 1 ligand (UNX), 2 pockets (best druggability 0.51). MolNFT v1 #111853 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4Z30
Type: protein
Length: 294 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Roquin-2
UniProt: Q9HBD1
Ligands: UNX
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 67% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Roquin-2	protein	294	67% helix, 3% strand	Q9HBD1

Ligands and binding sites

UNX · Unknown atom or ion · ion · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	250	0.51	0.75	29	empty
2	65	0.37	0.78	17	empty

Compared structures

4Z30 · Crystal structure of the ROQ domain of human Roquin-2 · the same entry in another collection · chain A against A, TM-score 1.00
Q9HBD1 · AlphaFold monomer V2.0 prediction for roquin-2 (Q9HBD1) · a predicted model of the same protein · chain A against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HBD1
Elsewhere: RCSB PDB 4Z30 · PDBe 4Z30 · UniProt Q9HBD1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.