MolNFT v1 · #111761 · protein
Structure of the impdh from ashbya gossypii bound to gmp
4Z0G · Inosine-5'-monophosphate DEHYDROGENASE,INOSINE-5'…: “Structure of the impdh from ashbya gossypii bound to gmp”. X-ray diffraction, 2 ligands (5GP, K), 10 pockets (best druggability 0.74). MolNFT v1 #111761 on GenesisL1: 3D…
- PDB
- 4Z0G
- Type
- protein
- Length
- 774 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inosine-5'-monophosphate DEHYDROGENASE,INOSINE-5'- monophosphate dehydrogenase
- EC
- 1.1.1.205
- UniProt
- Q756Z6
- Ligands
- 5GP, K
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inosine-5'-monophosphate DEHYDROGENASE,INOSINE-5'- monophosphate dehydrogenase (EC 1.1.1.205) | protein | 384 | 38% helix, 17% strand | Q756Z6 |
| B | Inosine-5'-monophosphate DEHYDROGENASE,INOSINE-5'- monophosphate dehydrogenase (EC 1.1.1.205) | protein | 390 | 37% helix, 17% strand | Q756Z6 |
Ligands and binding sites
- 5GP · Guanosine-5'-monophosphate · ligand · 4 copies · chains A, B
- K · Potassium ion · metal · 2 copies · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 345 | 0.74 | 0.85 | 39 | 5GP, GOL |
| 2 | 327 | 0.73 | 0.85 | 40 | 5GP, GOL |
| 3 | 604 | 0.69 | 0.78 | 53 | empty |
| 4 | 142 | 0.52 | 0.80 | 23 | empty |
| 5 | 105 | 0.49 | 0.81 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 183 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4Z0G · Structure of the IMPDH from Ashbya gossypii bound to GMP · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q756Z6
- Elsewhere: RCSB PDB 4Z0G · PDBe 4Z0G · UniProt Q756Z6
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