MolNFT v1 · #111646 · protein
Crystal structure of the extracellular receptor domain of the essential sensor kinase walk from staphylococcus aureus
4YWZ · Sensor protein kinase walk: “Crystal structure of the extracellular receptor domain of the essential sensor kinase walk from…”. X-ray diffraction, 1 pocket (best druggability 0.74). MolNFT v1 #111646 on GenesisL1: 3D structure…
- PDB
- 4YWZ
- Type
- protein
- Length
- 293 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensor protein kinase walk
- EC
- 2.7.13.3
- UniProt
- Q2YUQ2
- Pockets
- 1 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensor protein kinase walk (EC 2.7.13.3) | protein | 147 | 46% helix, 31% strand | Q2YUQ2 |
| B | Sensor protein kinase walk (EC 2.7.13.3) | protein | 146 | 45% helix, 31% strand | Q2YUQ2 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 224 | 0.74 | 0.89 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 1087 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (engineered).
Compared structures
- 4YWZ · Crystal structure of the extracellular receptor domain of the essential sensor kinase… · the same entry in another collection · chain A against A, TM-score 1.00
- Q2YUQ2 · AlphaFold monomer V2.0 prediction for sensor protein kinase walk (Q2YUQ2) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2YUQ2
- Elsewhere: RCSB PDB 4YWZ · PDBe 4YWZ · UniProt Q2YUQ2
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