MolNFT v1 · #111546 · protein
Crystal structure of a tetramer of GLUA2 tr mutant ligand binding domains bound with glutamate at 1.26 ångström resolution
4YU0 · Glutamate receptor 2,GLUTAMATE receptor 2: “Crystal structure of a tetramer of GLUA2 tr mutant ligand binding domains bound with glutamate at 1.26…”. X-ray diffraction, 2 ligands (GLU, PO4), 4 pockets (best druggability 0.72).…
- PDB
- 4YU0
- Type
- protein
- Length
- 518 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2,GLUTAMATE receptor 2
- UniProt
- P19491
- Ligands
- GLU, PO4
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glutamate receptor 2,GLUTAMATE receptor 2 | protein | 259 | 38% helix, 21% strand | P19491 |
Ligands and binding sites
- GLU · Glutamic acid · ligand · 2 copies · chains A, B
- PO4 · Phosphate ion · ion · 6 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 860 | 0.72 | 0.77 | 76 | PO4 |
| 2 | 123 | 0.42 | 0.76 | 24 | PO4 |
| 3 | 100 | 0.37 | 0.75 | 24 | empty |
| 4 | 86 | 0.35 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 374 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4YU0 · Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with… · the same entry in another collection · chain A against A, TM-score 1.00
- P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19491
- Elsewhere: RCSB PDB 4YU0 · PDBe 4YU0 · UniProt P19491
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