MolNFT v1 · #111247 · protein
Crystal structure of the CRUMBS/MOESIN complex
4YL8: “Crystal structure of the CRUMBS/MOESIN complex”. X-ray diffraction, 1 ligand (IOD), 3 pockets (best druggability 0.70). MolNFT v1 #111247 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4YL8
- Type
- protein
- Length
- 327 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Moesin; Protein crumbs
- UniProt
- P26041, P10040
- Ligands
- IOD
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Moesin | protein | 296 | 37% helix, 24% strand | P26041 |
| B | Protein crumbs | protein | 31 | 0% helix, 19% strand | P10040 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 574 | 0.70 | 0.78 | 53 | IOD |
| 2 | 100 | 0.40 | 0.77 | 17 | empty |
| 3 | 51 | 0.35 | 0.79 | 19 | IOD |
Interfaces
1 interface between chains.
- A–B · 1404 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 4YL8 · Crystal structure of the Crumbs/Moesin complex · the same entry in another collection · chain A against A, TM-score 1.00
- P26041 · AlphaFold monomer V2.0 prediction for moesin (P26041) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P10040 · AlphaFold monomer V2.0 prediction for protein crumbs (P10040) · a predicted model of the same protein · chain B against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26041
- Every structure of UniProt P10040
- Elsewhere: RCSB PDB 4YL8 · PDBe 4YL8 · UniProt P26041 · UniProt P10040
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