MolNFT v1 · #111239 · protein
Crystal structures of mpges-1 inhibitor complexes
4YL0 · Prostaglandin E synthase: “Crystal structures of mpges-1 inhibitor complexes”. X-ray diffraction, 2 ligands (4DZ, GSH). MolNFT v1 #111239 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4YL0
- Type
- protein
- Length
- 148 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prostaglandin E synthase
- EC
- 5.3.99.3
- UniProt
- O14684
- Ligands
- 4DZ, GSH
Structure
x-ray diffraction · 1 distinct chain · 80% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prostaglandin E synthase (EC 5.3.99.3) | protein | 148 | 80% helix, 1% strand | O14684 |
Ligands and binding sites
- 4DZ · 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile · ligand · chains A
- GSH · Glutathione · ligand · chains A
- BOG · octyl beta-D-glucopyranoside · additive · 2 copies · chains A
- PG4 · Tetraethylene glycol · additive · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14684
- Elsewhere: RCSB PDB 4YL0 · PDBe 4YL0 · UniProt O14684
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