UniProt O14684
Prostaglandin E synthase (O14684)
Prostaglandin E synthase (UniProt O14684), EC 1.11.1.-, 2.5.1.18: 28 experimental structures on GenesisL1, 8 ligands bound. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O14684
- Protein
- Prostaglandin E synthase
- EC
- 1.11.1.-, 2.5.1.18, 5.3.99.3
- Experimental structures
- 28
- Predicted models
- 0
- Ligands
- 8
Structures
28 records of O14684 in the MolNFT archive: 28 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3DWW | Electron crystallographic structure of human microsomal prostaglandin E synthase 1 | electron crystallography | A, B, C | — | — |
| 3DWW | Electron crystallographic structure of human microsomal prostaglandin E synthase 1 | electron crystallography | A, B, C | — | — |
| 4AL0 | Crystal structure of Human PS-1 | x-ray diffraction | A | — | — |
| 4AL0 | Crystal structure of human ps-1 | x-ray diffraction | A | — | — |
| 4AL1 | Crystal structure of Human PS-1 GSH-analog complex | x-ray diffraction | A | — | — |
| 4AL1 | Crystal structure of human ps-1 gsh-analog complex | x-ray diffraction | A | — | — |
| 4BPM | Crystal structure of a human integral membrane enzyme | x-ray diffraction | A | — | — |
| 4BPM | Crystal structure of a human integral membrane enzyme | x-ray diffraction | A | — | — |
| 4WAB | Crystal structure of mPGES1 solved by native-SAD phasing | x-ray diffraction | A | — | — |
| 4WAB | Crystal structure of MPGES1 solved by native-sad phasing | x-ray diffraction | A | — | — |
| 4YK5 | Crystal Structures of mPGES-1 Inhibitor Complexes | x-ray diffraction | A | — | — |
| 4YK5 | Crystal structures of mpges-1 inhibitor complexes | x-ray diffraction | A | — | — |
| 4YL0 | Crystal Structures of mPGES-1 Inhibitor Complexes | x-ray diffraction | A | — | — |
| 4YL0 | Crystal structures of mpges-1 inhibitor complexes | x-ray diffraction | A | — | — |
| 4YL1 | Crystal Structures of mPGES-1 Inhibitor Complexes | x-ray diffraction | A | — | — |
| 4YL1 | Crystal structures of mpges-1 inhibitor complexes | x-ray diffraction | A | — | — |
| 4YL3 | Crystal Structures of mPGES-1 Inhibitor Complexes | x-ray diffraction | A | — | — |
| 4YL3 | Crystal structures of mpges-1 inhibitor complexes | x-ray diffraction | A | — | — |
| 5BQG | Crystal structure of mpges-1 bound to an inhibitor | x-ray diffraction | A | — | — |
| 5BQH | Discovery of a potent and selective mpges-1 inhibitor for the treatment of pain | x-ray diffraction | A | — | — |
| 5BQI | Discovery of a potent and selective mpges-1 inhibitor for the treatment of pain | x-ray diffraction | A | — | — |
| 5K0I | MPGES1 bound to an inhibitor | x-ray diffraction | A | — | — |
| 5T36 | Crystal structure of mpges-1 bound to inhibitor | x-ray diffraction | A | 755, GSH | — |
| 5T37 | Crystal structure of mpges-1 bound to inhibitor | x-ray diffraction | A | 758, GSH | — |
| 5TL9 | Crystal structure of mpges-1 bound to inhibitor | x-ray diffraction | A | 7DN, GSH, JZR | — |
| 6VL4 | Crystal structure of mpges-1 bound to dg-031 | x-ray diffraction | A | QY1 | — |
| 8PYV | Structure of Human PS-1 GSH-analog complex, solved at wavelength 2.755 A | x-ray diffraction | A | PLM, 48T | — |
| O14684 | AlphaFold monomer V2.0 prediction for prostaglandin E synthase (O14684) | — | — | — |
Ligands
- GSH · Glutathione · in 3 records
- 48T · L-gamma-glutamyl-S-(2-biphenyl-4-yl-2-oxoethyl)-L-cysteinylglycine · in 1 record
- 755 · 4-chloro-2-[({(1S,2S)-2-[(2,2-dimethylpropanoyl) amino]cyclopentyl}methyl)amino]benzoic acid · in 1 record
- 758 · 2-chloro-5-{[(2,2-dimethylpropanoyl)amino]methyl}-N-(1H-imidazol-2-yl)benzamide · in 1 record
- 7DN · 2-{2-[(1S,2S)-2-{[1-(8-methylquinolin-2-yl)piperidine-4-carbonyl]amino}cyclopentyl]ethyl}benzoic acid · in 1 record
- JZR · Hexyl beta-D-glucopyranoside · in 1 record
- PLM · Palmitic acid · in 1 record
- QY1 · (2R)-cyclopentyl{4-[(quinolin-2-yl) methoxy]phenyl}acetic acid · in 1 record
Elsewhere
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