Crystal structure of BCL-xl in complex with the bim BH3 domain containing ILE155-to-arg and GLU158-to-phosphoserine mutations

Structure

x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).

Ligands and binding sites

• NLG · N-acetyl-L-glutamate · ligand · chains A, B
• CL · Chloride ion · ion · 2 copies · chains A, B
• ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1006 Ų buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).

Compared structures

• 4YJ4 · Crystal structure of Bcl-xL in complex with the BIM BH3 domain containing Ile155-to-Arg… · the same entry in another collection · chain A against A, TM-score 1.00
• Q64373 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q64373) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q64373
• Elsewhere: RCSB PDB 4YJ4 · PDBe 4YJ4 · UniProt Q64373