MolNFT v1 · #11055 · protein

Unmyristoylated gcap-2 with three calcium ions bound

1JBA · Protein (guanylate cyclase activating protein 2): “Unmyristoylated gcap-2 with three calcium ions bound”. Solution nmr, 1 ligand (CA), 5 pockets (best druggability 0.68). MolNFT v1 #11055 on GenesisL1: 3D structure, binding sites…

PDB: 1JBA
Type: protein
Length: 189 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (guanylate cyclase activating protein 2)
EC: 4.6.1.2
UniProt: P51177
Ligands: CA
Pockets: 5 · best druggability 0.68

Structure

solution nmr · 1 distinct chain · 55% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (guanylate cyclase activating protein 2) (EC 4.6.1.2)	protein	189	55% helix, 3% strand	P51177

Ligands and binding sites

CA · Calcium ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	343	0.68	0.81	40	empty
2	198	0.48	0.75	30	empty
3	77	0.42	0.79	12	empty
4	63	0.41	0.81	16	empty
5	58	0.26	0.72	14	empty

Compared structures

1JBA · Unmyristoylated gcap-2 with three calcium ions bound · the same entry in another collection · chain A against A, TM-score 1.00
P51177 · AlphaFold monomer V2.0 prediction for guanylyl cyclase-activating protein 2 (P51177) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51177
Elsewhere: RCSB PDB 1JBA · PDBe 1JBA · UniProt P51177

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