MolNFT v1 · #110099 · protein

Crystal structure of nitrophorin 7 from rhodnius prolixus at pH 7.8 complexed with histamine

4XMF · Nitrophorin-7: “Crystal structure of nitrophorin 7 from rhodnius prolixus at pH 7.8 complexed with histamine”. X-ray diffraction, 2 ligands (HEM, HSM), 1 pocket (best druggability 0.68). MolNFT v1 #110099 on GenesisL1: 3D structure…

PDB: 4XMF
Type: protein
Length: 184 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nitrophorin-7
EC: 1.7.6.1
UniProt: Q6PQK2
Ligands: HEM, HSM
Pockets: 1 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nitrophorin-7 (EC 1.7.6.1)	protein	184	11% helix, 46% strand	Q6PQK2

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
HSM · Histamine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	347	0.68	0.81	33	HEM, HSM

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4XMF · Crystal structure of nitrophorin 7 from Rhodnius prolixus at pH 7.8 complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
Q6PQK2 · AlphaFold monomer V2.0 prediction for nitrophorin-7 (Q6PQK2) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6PQK2
Elsewhere: RCSB PDB 4XMF · PDBe 4XMF · UniProt Q6PQK2

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