MolNFT v1 · #109893 · protein
Crystal structure of an inhibitor-bound syk
4XG6 · Tyrosine-protein kinase syk: “Crystal structure of an inhibitor-bound syk”. X-ray diffraction, 1 ligand (X6G), 1 pocket (best druggability 0.64). MolNFT v1 #109893 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4XG6
- Type
- protein
- Length
- 271 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase syk
- EC
- 2.7.10.2
- UniProt
- P43405
- Ligands
- X6G
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase syk (EC 2.7.10.2) | protein | 271 | 39% helix, 23% strand | P43405 |
Ligands and binding sites
- X6G · 1-[(1-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 289 | 0.64 | 0.81 | 35 | X6G |
Compared structures
- 4XG6 · Crystal structure of an inhibitor-bound Syk · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43405
- Elsewhere: RCSB PDB 4XG6 · PDBe 4XG6 · UniProt P43405
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