MolNFT v1 · #109855 · protein

Cysteine dioxygenase variant - Y157F at pH 8.0 with cysteine

4XF1 · Cysteine dioxygenase type 1: “Cysteine dioxygenase variant - Y157F at pH 8.0 with cysteine”. X-ray diffraction, 2 ligands (CYS, FE), 1 pocket (best druggability 0.58). MolNFT v1 #109855 on GenesisL1: 3D structure, binding sites and…

PDB: 4XF1
Type: protein
Length: 186 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cysteine dioxygenase type 1
EC: 1.13.11.20
UniProt: P21816
Ligands: CYS, FE
Pockets: 1 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cysteine dioxygenase type 1 (EC 1.13.11.20)	protein	186	15% helix, 37% strand	P21816

Ligands and binding sites

CYS · Cysteine · ligand · chains A
FE · Fe (III) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	108	0.58	0.85	29	CYS

Compared structures

4XF1 · cysteine dioxygenase variant - Y157F at pH 8.0 with cysteine · the same entry in another collection · chain A against A, TM-score 1.00
P21816 · AlphaFold monomer V2.0 prediction for cysteine dioxygenase type 1 (P21816) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21816
Elsewhere: RCSB PDB 4XF1 · PDBe 4XF1 · UniProt P21816

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