MolNFT v1 · #109783 · protein
Methyltransferase domain of small RNA 2'-O-methyltransferase
4XCX: “Methyltransferase domain of small RNA 2'-O-methyltransferase”. X-ray diffraction, 1 ligand (SAH), 1 pocket (best druggability 0.47). MolNFT v1 #109783 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4XCX
- Type
- protein
- Length
- 216 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small RNA 2'-O-methyltransferase
- EC
- 2.1.1.-
- UniProt
- Q5T8I9
- Ligands
- SAH
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Small RNA 2'-O-methyltransferase (EC 2.1.1.-) | protein | 216 | 34% helix, 25% strand | Q5T8I9 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.47 | 0.77 | 26 | SAH |
Compared structures
- 4XCX · Methyltransferase domain of small RNA 2'-O-methyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
- Q5T8I9 · AlphaFold monomer V2.0 prediction for small RNA 2'-O-methyltransferase (Q5T8I9) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5T8I9
- Elsewhere: RCSB PDB 4XCX · PDBe 4XCX · UniProt Q5T8I9
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