MolNFT v1 · #109669 · protein

Crystal structure of bovine annexin A2

4X9P: “Crystal structure of bovine annexin A2”. X-ray diffraction, 2 ligands (CA, CL), 2 pockets (best druggability 0.50). MolNFT v1 #109669 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4X9P
Type: protein
Length: 314 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin A2
UniProt: P04272
Ligands: CA, CL
Pockets: 2 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin A2	protein	314	72% helix, 0% strand	P04272

Ligands and binding sites

CA · Calcium ion · metal · 3 copies · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	107	0.50	0.81	28	empty
2	126	0.50	0.80	38	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4X9P · Crystal structure of bovine Annexin A2 · the same entry in another collection · chain A against A, TM-score 1.00
P04272 · AlphaFold monomer V2.0 prediction for annexin A2 (P04272) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04272
Elsewhere: RCSB PDB 4X9P · PDBe 4X9P · UniProt P04272

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