MolNFT v1 · #109613 · protein
Crystal structure of the extracellular domain of ZIP4
4X82 · Zinc transporter ZIP4: “Crystal structure of the extracellular domain of ZIP4”. X-ray diffraction, 5 pockets (best druggability 0.38). MolNFT v1 #109613 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4X82
- Type
- protein
- Length
- 444 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc transporter ZIP4
- UniProt
- L5KLU7
- Pockets
- 5 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Zinc transporter ZIP4 | protein | 217 | 66% helix, 2% strand | L5KLU7 |
| A | Zinc transporter ZIP4 | protein | 227 | 63% helix, 2% strand | L5KLU7 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 84 | 0.38 | 0.76 | 17 | empty |
| 2 | 66 | 0.36 | 0.78 | 20 | empty |
| 3 | 57 | 0.30 | 0.75 | 15 | empty |
| 4 | 66 | 0.29 | 0.73 | 17 | empty |
| 5 | 53 | 0.28 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- B–A · 1758 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 4X82 · Crystal Structure of the Extracellular Domain of ZIP4 · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt L5KLU7
- Elsewhere: RCSB PDB 4X82 · PDBe 4X82 · UniProt L5KLU7
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