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Crystal structure of the extracellular domain of ZIP4

Analyse Crystal structure of the extracellular domain of ZIP4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4X82
Type: protein
Length: 444 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Zinc transporter ZIP4
UniProt: L5KLU7
Pockets: 5 · best druggability 0.38

Structure

x-ray diffraction · 2 distinct chains · 64% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Zinc transporter ZIP4	protein	217	66% helix, 2% strand	L5KLU7
A	Zinc transporter ZIP4	protein	227	63% helix, 2% strand	L5KLU7

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.38	0.76	17	empty
2	66	0.36	0.78	20	empty
3	57	0.30	0.75	15	empty
4	66	0.29	0.73	17	empty
5	53	0.28	0.75	17	empty

Interfaces

1 interface between chains.

B–A · 1758 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

4X82 · Crystal Structure of the Extracellular Domain of ZIP4 · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt L5KLU7
Elsewhere: RCSB PDB 4X82 · PDBe 4X82 · UniProt L5KLU7

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