MolNFT v1 · #109597 · protein

Crystal structure of S. aureus tarm G117R mutant in complex with udp and udp-glcnac

4X7M: “Crystal structure of S. aureus tarm G117R mutant in complex with udp and udp-glcnac”. X-ray diffraction, 2 ligands (UDP, UD1), 7 pockets (best druggability 0.78). MolNFT v1 #109597 on GenesisL1: 3D structure, binding sites and…

PDB: 4X7M
Type: protein
Length: 986 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tarm
UniProt: H0AM96
Ligands: UDP, UD1
Pockets: 7 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Tarm	protein	493	35% helix, 26% strand	H0AM96

Ligands and binding sites

UDP · Uridine-5'-diphosphate · ligand · chains A
UD1 · Uridine-diphosphate-N-acetylglucosamine · ligand · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	579	0.78	0.84	69	UD1
2	754	0.73	0.79	66	UDP
3	133	0.53	0.81	21	empty
4	136	0.47	0.78	23	empty
5	152	0.43	0.75	25	empty

Interfaces

1 interface between chains.

A–B · 245 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

4X7M · Crystal structure of S. aureus TarM G117R mutant in complex with UDP and UDP-GlcNAc · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H0AM96
Elsewhere: RCSB PDB 4X7M · PDBe 4X7M · UniProt H0AM96

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.