MolNFT v1 · #109577 · protein
An isoform-specific myristylation switch targets riib PKA holoenzymes to membranes
4X6Q · Camp-dependent protein kinase type II-beta regulatory…: “An isoform-specific myristylation switch targets riib PKA holoenzymes to membranes”. X-ray diffraction, 9 pockets (best druggability 0.78). MolNFT v1 #109577 on GenesisL1: 3D…
- PDB
- 4X6Q
- Type
- protein
- Length
- 607 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camp-dependent protein kinase type II-beta regulatory subunit; Camp-dependent protein…
- EC
- 2.7.11.11
- UniProt
- P31324, P05132
- Pockets
- 9 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Camp-dependent protein kinase type II-beta regulatory subunit | protein | 270 | 27% helix, 33% strand | P31324 |
| C | Camp-dependent protein kinase catalytic subunit alpha (EC 2.7.11.11) | protein | 337 | 38% helix, 16% strand | P05132 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 369 | 0.78 | 0.88 | 55 | empty |
| 2 | 710 | 0.72 | 0.79 | 68 | empty |
| 3 | 85 | 0.49 | 0.82 | 12 | empty |
| 4 | 208 | 0.44 | 0.73 | 35 | empty |
| 5 | 134 | 0.43 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- B–C · 2030 Ų buried · 38 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (phosphorylation).
Compared structures
- 4X6Q · An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes · the same entry in another collection · chain B against B, TM-score 1.00
- P31324 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type II-beta… · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31324
- Every structure of UniProt P05132
- Elsewhere: RCSB PDB 4X6Q · PDBe 4X6Q · UniProt P31324 · UniProt P05132
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