MolNFT v1 · #109452 · protein
Crystal structure of the 53BP1 tandem tudor domain in complex with P53K381ACK382ME2
4X34 · Tumor suppressor P53-binding protein 1: “Crystal structure of the 53BP1 tandem tudor domain in complex with P53K381ACK382ME2”. X-ray diffraction, 2 pockets (best druggability 0.44). MolNFT v1 #109452 on GenesisL1: 3D structure…
- PDB
- 4X34
- Type
- protein
- Length
- 257 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor suppressor P53-binding protein 1; Thr-ser-arg-his-aly-mly-leu-met-phe-lys
- UniProt
- Q12888
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 4 distinct chains · 15% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tumor suppressor P53-binding protein 1 | protein | 120 | 14% helix, 52% strand | Q12888 |
| B | Tumor suppressor P53-binding protein 1 | protein | 119 | 14% helix, 54% strand | Q12888 |
| C | Thr-ser-arg-his-aly-mly-leu-met-phe-lys | protein | 10 | 50% helix, 0% strand | — |
| D | Thr-ser-arg-his-aly-mly-leu-met-phe-lys | protein | 8 | 0% helix, 0% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 173 | 0.44 | 0.74 | 26 | empty |
| 2 | 91 | 0.39 | 0.76 | 20 | empty |
Interfaces
3 interfaces between chains.
- B–D · 498 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 476 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 327 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (acetylation, methylation).
Compared structures
- 4X34 · Crystal structure of the 53BP1 tandem tudor domain in complex with p53K381acK382me2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q12888 · AlphaFold monomer V2.0 prediction for TP53-binding protein 1 (Q12888) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12888
- Elsewhere: RCSB PDB 4X34 · PDBe 4X34 · UniProt Q12888
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