MolNFT v1 · #10938 · protein
Anthrax toxin lethal factor
1J7N · Lethal factor precursor: “Anthrax toxin lethal factor”. X-ray diffraction, 2 ligands (ZN, SO4), 20 pockets (best druggability 0.84). MolNFT v1 #10938 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1J7N
- Type
- protein
- Length
- 1,461 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lethal factor precursor
- UniProt
- P15917
- Ligands
- ZN, SO4
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lethal factor precursor | protein | 725 | 52% helix, 14% strand | P15917 |
| B | Lethal factor precursor | protein | 736 | 54% helix, 13% strand | P15917 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 561 | 0.84 | 0.90 | 70 | SO4 |
| 2 | 241 | 0.77 | 0.90 | 34 | empty |
| 3 | 373 | 0.66 | 0.80 | 54 | empty |
| 4 | 52 | 0.66 | 0.96 | 20 | empty |
| 5 | 230 | 0.63 | 0.82 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 1324 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15917
- Elsewhere: RCSB PDB 1J7N · PDBe 1J7N · UniProt P15917
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.