MolNFT v1 · #109327 · protein

Crystal structural basis for RV0315, an immunostimulatory antigen and pseudo beta-1, 3-glucanase of mycobacterium tuberculosis

4WZF · 1,3-beta-glucanase: “Crystal structural basis for RV0315, an immunostimulatory antigen and pseudo beta-1, 3-glucanase of…”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.55). MolNFT v1 #109327 on GenesisL1: 3D…

PDB: 4WZF
Type: protein
Length: 481 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1,3-beta-glucanase
UniProt: O07242
Ligands: CA
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	1,3-beta-glucanase	protein	240	4% helix, 45% strand	O07242
B	1,3-beta-glucanase	protein	241	4% helix, 45% strand	O07242

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A, B
EDO · 1,2-ethanediol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	338	0.55	0.74	39	EDO
2	323	0.54	0.74	35	EDO

Compared structures

4WZF · Crystal structural basis for Rv0315, an immunostimulatory antigen and pseudo beta-1… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O07242
Elsewhere: RCSB PDB 4WZF · PDBe 4WZF · UniProt O07242

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