MolNFT v1 · #109240 · protein
Structure of MEX67:MTR2
4WWU · MRNA export factor MEX67: “Structure of MEX67:MTR2”. X-ray diffraction, 1 ligand (ZN), 20 pockets (best druggability 0.83). MolNFT v1 #109240 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4WWU
- Type
- protein
- Length
- 2,349 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MRNA export factor MEX67; MRNA transport regulator MTR2
- UniProt
- Q99257, P34232
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 10 distinct chains · 31% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, J | MRNA export factor MEX67 | protein | 71 | 28% helix, 24% strand | Q99257 |
| B | MRNA export factor MEX67 | protein | 347 | 33% helix, 24% strand | Q99257 |
| C | MRNA transport regulator MTR2 | protein | 165 | 25% helix, 36% strand | P34232 |
| D, G | MRNA export factor MEX67 | protein | 69 | 29% helix, 25% strand | Q99257 |
| E | MRNA export factor MEX67 | protein | 349 | 33% helix, 22% strand | Q99257 |
| F | MRNA transport regulator MTR2 | protein | 164 | 25% helix, 35% strand | P34232 |
| H | MRNA export factor MEX67 | protein | 363 | 31% helix, 23% strand | Q99257 |
| I | MRNA transport regulator MTR2 | protein | 161 | 27% helix, 35% strand | P34232 |
| K | MRNA export factor MEX67 | protein | 358 | 33% helix, 24% strand | Q99257 |
| L | MRNA transport regulator MTR2 | protein | 162 | 27% helix, 37% strand | P34232 |
Ligands and binding sites
- ZN · Zinc ion · metal · 12 copies · chains B, C, L, E, F, I, G, H, J, K
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1172 | 0.83 | 0.84 | 116 | empty |
| 2 | 1149 | 0.81 | 0.82 | 104 | empty |
| 3 | 591 | 0.73 | 0.80 | 64 | empty |
| 4 | 164 | 0.63 | 0.85 | 26 | empty |
| 5 | 203 | 0.58 | 0.80 | 25 | ZN |
Interfaces
16 interfaces between chains.
- E–F · 3070 Ų buried · 39 hydrogen bonds · protein-protein
- B–C · 3070 Ų buried · 39 hydrogen bonds · protein-protein
- H–I · 3070 Ų buried · 31 hydrogen bonds · protein-protein
- K–L · 3051 Ų buried · 38 hydrogen bonds · protein-protein
- F–I · 734 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- Q99257 · AlphaFold monomer V2.0 prediction for mRNA export factor MEX67 (Q99257) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P34232 · AlphaFold monomer V2.0 prediction for mRNA transport regulator MTR2 (P34232) · a predicted model of the same protein · chain L against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99257
- Every structure of UniProt P34232
- Elsewhere: RCSB PDB 4WWU · PDBe 4WWU · UniProt Q99257 · UniProt P34232
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