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Structure of MEX67:MTR2

Analyse Structure of MEX67:MTR2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4WWU
Type: protein
Length: 2,349 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MRNA export factor MEX67; MRNA transport regulator MTR2
UniProt: Q99257, P34232
Ligands: ZN
Pockets: 20 · best druggability 0.83

Structure

x-ray diffraction · 10 distinct chains · 31% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, J	MRNA export factor MEX67	protein	71	28% helix, 24% strand	Q99257
B	MRNA export factor MEX67	protein	347	33% helix, 24% strand	Q99257
C	MRNA transport regulator MTR2	protein	165	25% helix, 36% strand	P34232
D, G	MRNA export factor MEX67	protein	69	29% helix, 25% strand	Q99257
E	MRNA export factor MEX67	protein	349	33% helix, 22% strand	Q99257
F	MRNA transport regulator MTR2	protein	164	25% helix, 35% strand	P34232
H	MRNA export factor MEX67	protein	363	31% helix, 23% strand	Q99257
I	MRNA transport regulator MTR2	protein	161	27% helix, 35% strand	P34232
K	MRNA export factor MEX67	protein	358	33% helix, 24% strand	Q99257
L	MRNA transport regulator MTR2	protein	162	27% helix, 37% strand	P34232

Ligands and binding sites

ZN · Zinc ion · metal · 12 copies · chains B, C, L, E, F, I, G, H, J, K

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1172	0.83	0.84	116	empty
2	1149	0.81	0.82	104	empty
3	591	0.73	0.80	64	empty
4	164	0.63	0.85	26	empty
5	203	0.58	0.80	25	ZN

Interfaces

16 interfaces between chains.

E–F · 3070 Å² buried · 39 hydrogen bonds · protein-protein
B–C · 3070 Å² buried · 39 hydrogen bonds · protein-protein
H–I · 3070 Å² buried · 31 hydrogen bonds · protein-protein
K–L · 3051 Å² buried · 38 hydrogen bonds · protein-protein
F–I · 734 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

4WWU · Structure of Mex67:Mtr2 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99257
Every structure of UniProt P34232
Elsewhere: RCSB PDB 4WWU · PDBe 4WWU · UniProt Q99257 · UniProt P34232

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