MolNFT v1 · #108879 · protein

Structure of wzze polysaccharide co-polymerase

4WL1 · Lipopolysaccharide biosynthesis protein wzze: “Structure of wzze polysaccharide co-polymerase”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #108879 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4WL1
Type: protein
Length: 7,072 residues
Chains: 32
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipopolysaccharide biosynthesis protein wzze
UniProt: P0AG01
Pockets: 20 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 63% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f	Lipopolysaccharide biosynthesis protein wzze	protein	221	63% helix, 11% strand	P0AG01

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	976	0.84	0.85	105	empty
2	709	0.83	0.86	68	empty
3	1054	0.75	0.78	91	empty
4	1130	0.75	0.77	83	empty
5	986	0.74	0.77	98	empty

Interfaces

43 interfaces between chains.

c–d · 1378 Å² buried · 18 hydrogen bonds · protein-protein
U–V · 1371 Å² buried · 15 hydrogen bonds · protein-protein
a–b · 1323 Å² buried · 21 hydrogen bonds · protein-protein
M–N · 1306 Å² buried · 18 hydrogen bonds · protein-protein
e–f · 1306 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

4WL1 · Structure of WzzE Polysaccharide Co-polymerase · the same entry in another collection · chain c against c, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0AG01
Elsewhere: RCSB PDB 4WL1 · PDBe 4WL1 · UniProt P0AG01

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