MolNFT v1 · #108801 · protein

Crystal structure of camp-dependent protein kinase a from cricetulus griseus

4WIH · Camp-dependent protein kinase catalytic subunit alpha: “Crystal structure of camp-dependent protein kinase a from cricetulus griseus”. X-ray diffraction, 3 pockets (best druggability 0.80). MolNFT v1 #108801 on GenesisL1: 3D…

PDB: 4WIH
Type: protein
Length: 368 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Camp-dependent protein kinase catalytic subunit alpha; Camp dependent protein kinase…
EC: 2.7.11.11
UniProt: P25321
Pockets: 3 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Camp-dependent protein kinase catalytic subunit alpha (EC 2.7.11.11)	protein	353	39% helix, 15% strand	P25321
B	Camp dependent protein kinase inhibitor pki-tide	protein	15	0% helix, 7% strand	—

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	294	0.80	0.91	39	empty
2	125	0.58	0.84	23	empty
3	93	0.34	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 983 Å² buried · 29 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 modified (phosphorylation).

Compared structures

4WIH · Crystal structure of cAMP-dependent Protein Kinase A from Cricetulus griseus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25321
Elsewhere: RCSB PDB 4WIH · PDBe 4WIH · UniProt P25321

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