MolNFT v1 · #108718 · protein
Manganese-substituted soybean lipoxygenase-1
4WFO · Seed linoleate 13S-lipoxygenase-1: “Manganese-substituted soybean lipoxygenase-1”. X-ray diffraction, 1 ligand (MN), 13 pockets (best druggability 0.82). MolNFT v1 #108718 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4WFO
- Type
- protein
- Length
- 826 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Seed linoleate 13S-lipoxygenase-1
- EC
- 1.13.11.12
- UniProt
- P08170
- Ligands
- MN
- Pockets
- 13 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Seed linoleate 13S-lipoxygenase-1 (EC 1.13.11.12) | protein | 826 | 43% helix, 15% strand | P08170 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · chains A
- EDO · 1,2-ethanediol · additive · 8 copies · chains A
- ACT · Acetate ion · additive · 6 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 716 | 0.82 | 0.86 | 74 | EDO |
| 2 | 94 | 0.78 | 0.98 | 29 | EDO |
| 3 | 389 | 0.69 | 0.81 | 43 | EDO |
| 4 | 291 | 0.56 | 0.77 | 37 | empty |
| 5 | 93 | 0.47 | 0.81 | 20 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08170
- Elsewhere: RCSB PDB 4WFO · PDBe 4WFO · UniProt P08170
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.