MolNFT v1 · #108501 · protein
Crystal structure of riam TBS1 in complex with talin R7R8 domains
4W8P · Talin-1: “Crystal structure of riam TBS1 in complex with talin R7R8 domains”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #108501 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4W8P
- Type
- protein
- Length
- 322 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Talin-1; Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
- UniProt
- P26039, Q8R5A3
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 80% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Talin-1 | protein | 301 | 80% helix, 1% strand | P26039 |
| B | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | protein | 21 | 76% helix, 0% strand | Q8R5A3 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.37 | 0.74 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 761 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4W8P · Crystal structure of RIAM TBS1 in complex with talin R7R8 domains · the same entry in another collection · chain A against A, TM-score 1.00
- P26039 · AlphaFold monomer V2.0 prediction for talin-1 (P26039) · a predicted model of the same protein · chain A against A, TM-score 0.82
- Q8R5A3 · AlphaFold monomer V2.0 prediction for amyloid beta A4 precursor protein-binding family B… · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26039
- Every structure of UniProt Q8R5A3
- Elsewhere: RCSB PDB 4W8P · PDBe 4W8P · UniProt P26039 · UniProt Q8R5A3
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