MolNFT v1 · #108350 · protein

Crystal structure of RV3557C/KSTR2, a transcriptional repressor involved in cholesterol metabolism in mycobacterium tuberculosis

4W1U · Hth-type transcriptional repressor KSTR2: “Crystal structure of RV3557C/KSTR2, a transcriptional repressor involved in cholesterol metabolism in…”. X-ray diffraction, 2 pockets (best druggability 0.60). MolNFT v1 #108350 on…

PDB: 4W1U
Type: protein
Length: 193 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hth-type transcriptional repressor KSTR2
UniProt: P9WMB9
Pockets: 2 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hth-type transcriptional repressor KSTR2	protein	193	73% helix, 0% strand	P9WMB9

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	180	0.60	0.82	24	empty
2	83	0.41	0.78	14	empty

Compared structures

4W1U · Crystal structure of Rv3557c/KstR2, a transcriptional repressor involved in cholesterol… · the same entry in another collection · chain A against A, TM-score 1.00
P9WMB9 · AlphaFold monomer V2.0 prediction for hth-type transcriptional repressor KSTR2 (P9WMB9) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WMB9
Elsewhere: RCSB PDB 4W1U · PDBe 4W1U · UniProt P9WMB9

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.