MolNFT v1 · #108319 · protein

The structure of ALPHA2,3-sialyltransferase variant 2 from pasteurella dagmatis in complex with the donor product cmp

4V3C: “The structure of ALPHA2,3-sialyltransferase variant 2 from pasteurella dagmatis in complex with the donor…”. X-ray diffraction, 1 ligand (C), 5 pockets (best druggability 0.69). MolNFT v1 #108319 on GenesisL1: 3D structure, binding…

PDB: 4V3C
Type: protein
Length: 388 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sialyltransferase
UniProt: K9UUI6
Ligands: C
Pockets: 5 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sialyltransferase	protein	388	42% helix, 17% strand	K9UUI6

Ligands and binding sites

C · Cytidine-5'-monophosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	470	0.69	0.80	49	C
2	100	0.47	0.80	15	empty
3	63	0.40	0.80	16	empty
4	73	0.37	0.77	15	empty
5	74	0.34	0.76	18	empty

Compared structures

4V3C · The structure of alpha2,3-sialyltransferase variant 2 from Pasteurella dagmatis in… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt K9UUI6
Elsewhere: RCSB PDB 4V3C · PDBe 4V3C · UniProt K9UUI6

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