MolNFT v1 · #108285 · protein
Mouse FLRT2 lrr domain in complex with rat UNC5D IG1 domain
4V2C · Fibronectin leucine rich transmembrane protein 2: “Mouse FLRT2 lrr domain in complex with rat UNC5D IG1 domain”. X-ray diffraction, 8 pockets (best druggability 0.75). MolNFT v1 #108285 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4V2C
- Type
- protein
- Length
- 858 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibronectin leucine rich transmembrane protein 2; Protein UNC5D
- UniProt
- Q8BLU0, F1LW30
- Pockets
- 8 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Fibronectin leucine rich transmembrane protein 2 | protein | 323 | 8% helix, 18% strand | Q8BLU0 |
| B, D | Protein UNC5D | protein | 106 | 8% helix, 51% strand | F1LW30 |
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.75 | 0.95 | 45 | empty |
| 2 | 643 | 0.73 | 0.80 | 78 | empty |
| 3 | 86 | 0.65 | 0.91 | 20 | empty |
| 4 | 475 | 0.65 | 0.78 | 55 | empty |
| 5 | 219 | 0.56 | 0.79 | 25 | empty |
Interfaces
5 interfaces between chains.
- A–C · 887 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 730 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 686 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 507 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 419 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 4V2C · mouse FLRT2 LRR domain in complex with rat Unc5D Ig1 domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q8BLU0 · AlphaFold monomer V2.0 prediction for leucine-rich repeat transmembrane protein FLRT2… · a predicted model of the same protein · chain C against A, TM-score 0.99
- F1LW30 · AlphaFold monomer V2.0 prediction for netrin receptor UNC5D (F1LW30) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8BLU0
- Every structure of UniProt F1LW30
- Elsewhere: RCSB PDB 4V2C · PDBe 4V2C · UniProt Q8BLU0 · UniProt F1LW30
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