MolNFT v1 · #108182 · protein
Structure of the wnt deacylase notum - crystal form III - 1.4A
4UZ1: “Structure of the wnt deacylase notum - crystal form III - 1.4A”. X-ray diffraction, 2 ligands (NAG, SO4), 2 pockets (best druggability 0.70). MolNFT v1 #108182 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4UZ1
- Type
- protein
- Length
- 358 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Notum
- EC
- 3.1.1.1
- UniProt
- Q6P988
- Ligands
- NAG, SO4
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Notum (EC 3.1.1.1) | protein | 358 | 34% helix, 17% strand | Q6P988 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
- SO4 · Sulfate ion · ion · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 131 | 0.70 | 0.91 | 24 | empty |
| 2 | 60 | 0.27 | 0.73 | 14 | empty |
Modifications
Observed in the structure: 7 disulfide, 1 glycan (disulfide, N-glycosylation).
Compared structures
- 4UZ1 · Structure of the wnt deacylase notum - crystal form III - 1.4A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P988
- Elsewhere: RCSB PDB 4UZ1 · PDBe 4UZ1 · UniProt Q6P988
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